2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-106487
    Pridefine 5370-41-2 98%
    Pridefine (AHR-1118) is an antidepressant agent.
    Pridefine
  • HY-106495
    Vadocaine 72005-58-4 98%
    Vadocaine (OR K-242), an orally active antitussive compound, is a local agent that can suppress or relieve pain.
    Vadocaine
  • HY-106507
    Batoprazine 105685-11-8 98%
    Batoprazine (8-(1-piperazinyl)-2H-1-benzopyran-2-one)) is a 5-HT1A,1B receptor agonist. Batoprazine can replace the behavioral stimulus of eltoprazine in the two-lever operant discrimination test between eltoprazine and deionized water in rats (ED50: 0.20 mg/kg).
    Batoprazine
  • HY-106516
    Napactadine free base 76631-45-3 98%
    Napactadine (free base) (compound 33) has anti-depressive activity. Napactadine has oral activity.
    Napactadine free base
  • HY-106547
    Rilmazafone 99593-25-6 98%
    Rilmazafone is a benzodiazepine (omega) ligand and an orally active sleep inducer.
    Rilmazafone
  • HY-106578
    Quinupramine 31721-17-2 98%
    Quinupramine is an orally active antidepressant. Quinupramine can penetrate into the CNS and affect some of the processes of neurotransmission. The antidepressant activity of quinupramine is associated with the central serotonin system, but not with the β-adrenergic system[1][2].
    Quinupramine
  • HY-106584
    Mosapramine 89419-40-9 98%
    Mosapramine (Clospipramine) is an orally active and potent dopamine receptor antagonist with high affinity to dopamine receptor subtypes 2, 3 and 4, and with moderate affinity for the 5-HT2 receptor. Mosapramine shows antipsychotic activity and can be used in schizophrenia research.
    Mosapramine
  • HY-106601
    Picenadol 79201-85-7 98%
    Picenadol (LY-150720) is an opioid mixed agonist-antagonist analgesic. Picenadol is an external racemic mixture, where its d-isomer (LY136596) is a potent μ-opioid receptor agonist, and the l-isomer (LY136595) is a weak μ-receptor competitive antagonist, which can inhibit the agonist effect and reduce the risk of dependence. Picenadol has anticholinergic activity.
    Picenadol
  • HY-106602
    Gevotroline 107266-06-8 98%
    Gevotroline has a high affinity for the 5-HT receptor. Gevotroline can be used in the research of antagonist psychotomimetic action.
    Gevotroline
  • HY-106635
    Suriclone 53813-83-5 98%
    Suriclone (RP31264) is a GABA receptor agonist. Suriclone is an anxiolytic agent with a high affinity for the benzodiazepine receptors. Suriclone has oral activity.
    Suriclone
  • HY-106645
    Cloxacepride 65569-29-1 98%
    Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity.
    Cloxacepride
  • HY-106646
    CQP-201403 81855-35-8 98%
    CQP-201403 is a dopamine receptor agonist. CQP-201403 can be used for the research of neurological disease.
    CQP-201403
  • HY-106652
    SUN-N8075 dimethanesulfonate 224450-56-0 98%
    SUN-N8075 (dimethanesulfonate) is a radical scavenger with antioxidant and neuroprotective effect. SUN-N8075 (dimethanesulfonate) can inhibit apoptosis and ROS production. SUN-N8075 (dimethanesulfonate) can protect against 6-OHDA (HY-B1081)-induced cell death. SUN-N8075 (dimethanesulfonate) can be used for the research of neurological disease, such as Parkinson's disease.
    SUN-N8075 dimethanesulfonate
  • HY-106659
    SCH 900978 873947-10-5 98%
    SCH 900978 (NK-1 Antagonist 1) is an antagonist of NK-1 receptor, used in the research of NK-1 related diseases and conditions such as cough, overactive bladder, alcohol dependency and depression.
    SCH 900978
  • HY-106660
    BP 897 hydrochloride 314776-92-6 99.84%
    BP 897 hydrochloride is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM).
    BP 897 hydrochloride
  • HY-106661
    GLY-230 320777-05-7 98%
    GLY-230 is an orally active compound. GLY-230 can inhibit nonenzymatic glycation and reduce glycated albumin. GLY-230 can reduce brain Aβ42 levels. GLY-230 can be used for the researches of metabolic and neurological disease, such as diabetic renal dysfunction.
    GLY-230
  • HY-106670
    Dulozafone 75616-02-3 98%
    Dulozafone (F1933) shows anticonvulsant activity and can be used for epilepsy research.
    Dulozafone
  • HY-106716
    SR 41378 93181-85-2 98%
    SR 41378 is an orally active aminopyrazine derivative. SR 41378 has anticonvulsant, antianxiety and hypnotic activities.
    SR 41378
  • HY-106732
    AT-076 1657028-64-2 98%
    AT-076 is an opioid pan antagonist at nociception, kappa, mu, and delta opioid receptors, with Ki values of 1.75 nM (NOP), 1.67 nM (MOP), 1.14 nM (KOP) and 19.6 nM (DOP), respectively.
    AT-076
  • HY-106736
    Etilefrine pivalate hydrochloride 42145-91-5 98%
    Etilefrine pivalate hydrochloride is an orally active compound and can be used for study of migraine headaches.
    Etilefrine pivalate hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity